Lassa fever (LF) is a viral zoonotic illness and a significant cause of morbidity and mortality in countries across West Africa, namely Benin, Guinea, Liberia, Nigeria, and Sierra Leone. Our results argue for further collaborative research in housing and environmental modification such as ceiling construction, food storage, and sanitation as prevention against zoonotic LASV transmission. These results present detailed knowledge about how humans live with and come into contact with rodents, including the LASV reservoir. Rodents are also perceived as a serious threat to food security. Patterns of contact are both unintentional and intentional and research participants reported high levels of contact with rodents (34.2% of respondents) and rodent fluids (52.8% of respondents). Building design and materials provide hiding and nesting places for rodents and lead to close proximity with humans. natalensis (57% of trapped rodents) and Rattus rattus (38% of trapped rodents). Rodents were frequently reported inside houses (92.4% of respondents), in which we predominantly trapped M. We use semi-structured interviews ( N = 51), a quantitative survey ( N = 429), direct observations, and a rodent ecology study to provide new insights into how the organization of domestic spaces brings together humans and rodents and creates pathways for infection in rural settlements in Bo District, Sierra Leone. Housing characteristics and domestic organization affect rodent density in and around households and villages, and are likely to be a risk factor for Lassa fever in humans where the reservoir exists. Zoonotic transmission occurs when humans are directly or indirectly exposed to fluids of the multimammate mouse, such as urine, saliva, and blood. The multimammate mouse ( Mastomys natalensis) is the reservoir for Lassa virus (LASV).
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